merck millipore,默克密理愽
  • merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem

  • merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem

    产品名称：GGTI-286 - CAS 171744-11-9 - Calbiochem
    产品型号：345878
    A potent, cell-permeable, and selective inhibitor of GGTase I.

    merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₃₁N₃O₃S171744-11-9
    描述
    概述 A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50 = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
    产品目录编号 345878
    品牌系列 Calbiochem®
    同义词 N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA
    参考
    参考 Bredel, M., et al. 1998. Neurosurgery 43, 124.
    Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293.
    Lerner, E.C., et al. 1997. Oncogene 15, 1283.
    Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770.
    产品信息
    CAS号 171744-11-9
    具有ATP竞争性 N
    形式 Glassy solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₂₃H₃₁N₃O₃S
    化学配方 C₂₃H₃₁N₃O₃S
    Molar Mass 429.6
    可逆 N
    结构配方图像
    生物信息
    主靶 Geranylgeranyltransferase (GGTase)
    主靶IC50 2 µM against GGTase
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,217699,Cdk1 Inhibitor IV, RO-3306 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,400076,Hypericin - CAS 548-04-9 - Calbiochem


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