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merck millipore,默克密理博,217699,Cdk1 Inhibitor IV, RO-3306 - Calbiochem
产品名称：Cdk1 Inhibitor IV, RO-3306 - Calbiochem
产品型号：217699
The Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,217699,Cdk1 Inhibitor IV, RO-3306 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₈H₁₃N₃OS₂ 描述 概述 A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721). 产品目录编号 217699 品牌系列 Calbiochem®
参考 参考 Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. 产品信息 具有ATP竞争性 Y 形式 Brown solid Hill配方 C₁₈H₁₃N₃OS₂ 化学配方 C₁₈H₁₃N₃OS₂ Molar Mass 351.5 可逆 N 结构配方图像 生物信息 主靶 Cdk1 主靶Ki 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,ACK5003NT,Amicon Pro Affinity Concentration Kit Ni-NTA with 3kDa Amicon Ultra-0.5 Device
下一件merck millipore产品：merck millipore,默克密理博,345878,GGTI-286 - CAS 171744-11-9 - Calbiochem
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