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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB15554-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-AT2 Receptor Antibody Alternate Names - Angiotensin II receptory type 2, AGTR2
- Angiotensin II receptory type 2
产品信息 格式 Purified 控制 - Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Detect AT2 Receptor using this Anti-AT2 Receptor Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:200-1:500 using ECL on rat brain and mouse MS1 cell lysate.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from the N-terminus of rat AT2 Receptor (Accession number P35351). 宿主 Rabbit 特异性 Recognizes AT2 Receptor (Angiotensin II receptory type 2, AGTR2). 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000686.4
Entrez基因汇总 Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an intergral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. 基因符号 - ATGR2
- AGTR2
- MRX88
- AT2
非反应性品种 - Human
纯化方法 Immunoaffinity purified UniProt编号 - P50052
UniProt汇总 FUNCTION: SwissProt: P50052 # Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
SIZE: 363 amino acids; 41184 Da
SUBUNIT: Interacts with MTUS1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.
SIMILARITY: SwissProt: P50052 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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