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merck millipore,默克密理博,341329,Fatostatin - CAS 298197-04-3 - Calbiochem
产品名称：Fatostatin - CAS 298197-04-3 - Calbiochem
产品型号：341329
A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 precursors to the active nuclear forms by blocking SREBPs-SCAP ER to Golgi translocation.
merck millipore,默克密理博,341329,Fatostatin - CAS 298197-04-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₁₈N₂S • HBr 298197-04-3 描述 概述 A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 (Sterol Regulatory Element Binding Proteins 1/2) precursors to the active nuclear forms (>95% inhibition at 20 µM in CHO-K1 cells) by blocking SREBPs-SCAP (SREBP Cleavage-Activating Protein) ER to Golgi translocation with little effect against the transcription activity of the mature SREBPs. Binding studies employing recombinant SCAP truncation constructs reveal that Fatostatin targets SCAP between aa 448 to 767 in a reversible manner and is of no effect against SREBP-SCAP interaction. Fatostatin effectively suppresses SREBPs-dependent cellular functions in vitro, such as insulin-induced 3T3-L1 adipogenesis (complete inhibition at ≤20 µg/ml) and IGF1-dependent DU-145 proliferation (IC50 = 100 nM), and exhibits in vivo efficacy in lowering blood glucose level (by 70%) and body weight (by 12%) of ob/ob mice over a 28-day treatment period (30 mg/kg daily i.p.) without affecting animal food intake or apparent adverse effects. 产品目录编号 341329 品牌系列 Calbiochem®
同义词 125B11, 2-Propyl-4-(4-(p-tolyl)thiazol-2-yl)pyridine, HBr, SREBP Processing Inhibitor II 参考 参考 Kamisuki, S., et al. 2009. Chem. Biol. 16, 882.
Choi, Y., et al. 2003. J. Biol. Chem. 278, 7320.产品信息 CAS号 298197-04-3 形式 Pale yellow solid Hill配方 C₁₈H₁₈N₂S • HBr 化学配方 C₁₈H₁₈N₂S • HBr Molar Mass 375.3 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem
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