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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10439 描述 Anti-PACSIN1 Antibody, NT Alternate Names - syndapin I
- protein kinase C and casein kinase substrate in neurons 1
背景信息 PACSINs, also known as syndapins, are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN1 has been implicated as playing a central role in synaptic vesicle recycling (Kessels, 2004). Expected molecular weight is 51 kDa. 产品信息 格式 Purified 控制 - Mouse brain lysate
演示 PBS containing 0.09% NaN3. 应用 应用 Anti-PACSIN1 Antibody, N-terminus detects level of PACSIN1 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
生物信息 免疫原品种 KLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN1. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody recognizes human PACSIN1. 品种反应性 MouseHuman Species Reactivity Note Human and mouse. Reactivity with other species has not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - Q9BY11
基因符号 - SDPI
- KIAA1379
- OTTHUMP00000016231
纯化方法 Protein G purfied UniProt编号 - Q9BY11
UniProt汇总 FUNCTION: May play a role in vesicle formation and transport. Ref.6
SUBUNIT STRUCTURE: Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) By similarity.
SUBCELLULAR LOCATION: CytoplasmBy similarity. Note= Colocalizes with dynamin I at vesicular structures in the cell body and neurites By similarity.
TISSUE SPECIFICITY: Highly expressed in brain and in a lesser extent in heart, pancreas and liver.
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.
SEQUENCE SIMILARITIES: Belongs to the PACSIN family.
Contains 1 FCH domain.
Contains 1 SH3 domain.
产品使用声明 质量保证 Evaluated on a representative lot by Western blot on mouse brain lysate using a 1:100 - 1:500 dilution of Anti-PACSIN1. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage. 包装信息 数量 100 µg
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