merck millipore,默克密理愽
  • merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

  • merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

    产品名称：Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem
    产品型号：217696
    The Cdk1 Inhibitor, CGP74514A, also referenced under CAS 190654-01-4, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation  More>>

    merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₄ClN₇190654-01-4
    描述
    概述 A cell-permeable and ATP competitive 2,6,9-substituted purine derivative that acts as a potent, selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Reported to affect the activities of other kinases only at much higher concentrations (IC50 = 6.1 µM, 125 µM, and > 10 µM for PKCα, PKA, and EGFR, respectively). Shown to induce mitochondrial damage and apoptosis (≥ 3 µM) in several human leukemia cell lines. At lower concentrations (~1 µM), an initial G2M cell cycle arrest was observed in U937 cells, which eventually lead to apoptosis.
    产品目录编号 217696
    品牌系列 Calbiochem®
    同义词 CGP74514A, N-(cis-2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine
    参考
    参考 Yu. C., et al. 2003. Cancer Res. 63, 1822.
    Dai, Y., et al. 2002. Cell Cycle 1, 143.
    Imbach, P., et al. 1999. Bioorg. Med. Chem. Lett. 9, 91.
    产品信息
    CAS号 190654-01-4
    具有ATP竞争性 Y
    声明 Sold under license from Novartis Pharma AG.
    形式 Off-white solid
    Hill配方 C₁₉H₂₄ClN₇
    化学配方 C₁₉H₂₄ClN₇
    Molar Mass 385.9
    可逆 N
    结构配方图像
    生物信息
    主靶 Cdk1/cyclin B
    主靶IC50 25 nM against Cdk1/cyclin B
    纯度 ≥ 95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217696,Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

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