merck millipore,默克密理博,MABF545,Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC	AHm	APC	Monoclonal Antibody

描述
产品目录编号	MABF545
描述	Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11
Alternate Names	CD152 Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4
背景信息	The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

产品信息
格式	APC
演示	Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

应用
应用	This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), APC & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).
主要应用	Flow Cytometry

生物信息
免疫原品种	Immunogen information for this antibody is proprietary information.
克隆	UC10-4F10-11
浓缩	0.2 mg/mL
宿主	Armenian Hamster
同种型	IgG
品种反应性	Mouse
抗体类型	Monoclonal Antibody
基因符号	Cd152 Ctla4
纯化方法	Size Exclusion Chromatography
UniProt编号	P09793

产品使用声明
质量保证	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.06 μg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

包装信息
数量	25 µg

merck millipore,默克密理博,MABF545,Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

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