merck millipore,默克密理博,341249,FAAH Inhibitor II - CAS 546141-08-6

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Merck Millipore 默克密理愽

merck millipore,默克密理博,341249,FAAH Inhibitor II - CAS 546141-08-6 - Calbiochem

经验配方	CAS号
C₂₀H₂₂N₂O₃	546141-08-6

描述
概述	A cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC₅₀ = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC₅₀ = 500 pM) and modulate anxiety in rats (ID₅₀ = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC₅₀ > 30 µM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). It also does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC₅₀ > 100 µM), as well as several ion-channels and neurotransmitter transporters.
产品目录编号	341249
品牌系列	Calbiochem®
同义词	URB597, Cyclohexylcarbamic acid-3ʹ-carbamoyl-biphenyl-3-yl Ester, 3ʹ-Carbamoyl-biphenyl-3-yl-cyclohexylcarbamate

参考
参考	Kathuria, S., et al. 2003. Nat. Med. 9, 76.

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot, purge with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,341249,FAAH Inhibitor II - CAS 546141-08-6 - Calbiochem

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