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品种反应性 主要应用 宿主 格式 抗体类型 R, M, H ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC30 描述 Anti-Endonuclease G Antibody Alternate Names - Endo G
- Endonuclease G, mitochondrial
背景信息 Endonuclease G (Endo G) is a vertebrate nuclease that is found in the mitochondria and is thought to be important in mitochondrial DNA (mtDNA) replication. Endo G has also been found to have apoptosis-inducing behavior. Endo G apoptosis is thought to be induced by benzyl isothiocyanate. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 cells
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Endonuclease G Antibody detects level of Endonuclease G & has been published & validated for use in IC. 主要应用 - Immunocytochemistry
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Endonuclease G. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Mouse and Human.
Predicted to react with Rat based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004426
Entrez基因汇总 The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq]. 基因符号 - ENDOG
纯化方法 Affinity Purified UniProt编号 - Q14249
UniProt汇总 FUNCTION: Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).
COFACTOR: Manganese or magnesium (By similarity).
SUBUNIT STRUCTURE: Homodimer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules (By similarity).
SEQUENCE SIMILARITIES: Belongs to the DNA/RNA non-specific endonuclease family.产品使用声明 质量保证 Evaluated by Immunocytochemistry in NIH/3T3 cells.
Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected Endonuclease G in NIH/3T3 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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