merck millipore,默克密理愽
  • merck millipore,默克密理博,324879,EIF2AK3 Activator, CCT020312 - Calbiochem

  • merck millipore,默克密理博,324879,EIF2AK3 Activator, CCT020312 - Calbiochem

    产品名称：EIF2AK3 Activator, CCT020312 - Calbiochem
    产品型号：324879
    The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.

    merck millipore,默克密理博,324879,EIF2AK3 Activator, CCT020312 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324879,EIF2AK3 Activator, CCT020312 - Calbiochem

    重要规格表

    经验配方
    C₃₁H₃₀Br₂N₄O₂
    描述
    概述 A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC50 = 4.2 µM) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI50 = 3.1 µM).
    产品目录编号 324879
    品牌系列 Calbiochem®
    同义词 6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312
    参考
    参考 Stockwell, S. R., et al. 2011. Plos One In press.
    产品信息
    形式 Yellowish-white solid
    Hill配方 C₃₁H₃₀Br₂N₄O₂
    化学配方 C₃₁H₃₀Br₂N₄O₂
    Molar Mass 650.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324879,EIF2AK3 Activator, CCT020312 - Calbiochem

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