merck millipore,默克密理愽
  • merck millipore,默克密理博,14-573,Pim1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-573,Pim1 Protein, active, 10 µg

    产品名称：Pim1 Protein, active, 10 µg
    产品型号：14-573
    Active, N-terminal GST-tagged recombinant human full length Pim-1, for use in Kinase Assays.

    merck millipore,默克密理博,14-573,Pim1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-573,Pim1 Protein, active, 10 µg

    描述
    产品目录编号 14-573
    品牌系列 Upstate
    商名
    • Upstate
    描述 Pim1 Protein, active, 10 µg
    概述 N-terminal GST-tagged recombinant human full length Pim-1
    应用
    应用 Active, N-terminal GST-tagged recombinant human full length Pim-1, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in E. coli cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002648.2
    Entrez基因汇总 The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001 [PubMed 11518967]).[supplied by OMIM]
    基因符号
    • PIM
    • PIM1
    蛋白靶 Pim-1
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 CAMK
    UniProt编号
    • P11309
    UniProt汇总 FUNCTION: SwissProt: P11309 # Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.
    COFACTOR: Manganese.
    SIZE: 404 amino acids; 45412 Da
    SUBUNIT: Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1, but not isoform 2, binds BMX.
    SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus. & Isoform 1: Cell membrane.
    TISSUE SPECIFICITY: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
    PTM: Autophosphorylated on both serine/threonine and tyrosine residues.
    SIMILARITY: SwissProt: P11309 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-573M when ordering the 250 µg size.

    merck millipore,默克密理博,14-573,Pim1 Protein, active, 10 µg

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