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merck millipore,默克密理博,260961,DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
产品名称：DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
产品型号：260961
The DNA-PK Inhibitor II, also referenced under CAS 154447-35-5, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>
merck millipore,默克密理博,260961,DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₅NO₃ 154447-35-5 描述 概述 A cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC50 of 0.23 µM. It is highly selective towards DNA-PK over PI3K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR. 产品目录编号 260961 品牌系列 Calbiochem®
同义词 NU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646 参考 参考 Willmore, E., et al. 2004. Blood,103, 4659.
Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.产品信息 CAS号 154447-35-5 具有ATP竞争性 Y 形式 Crystalline solid Hill配方 C₁₇H₁₅NO₃ 化学配方 C₁₇H₁₅NO₃ Molar Mass 281.3 可逆 Y 结构配方图像 生物信息 主靶 DNA-PK 主靶IC50 0.23 µM against DNA-PK 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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