merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN463,Anti-Dopamine D3 receptor Antibody, clone N331/19

  • merck millipore,默克密理博,MABN463,Anti-Dopamine D3 receptor Antibody, clone N331/19

    产品名称：Anti-Dopamine D3 receptor Antibody, clone N331/19
    产品型号：MABN463
    This Dopamine D3 receptor antibody is validated for use in IHC & ICC for the detection of the Dopamine D3 receptor protein.

    merck millipore,默克密理博,MABN463,Anti-Dopamine D3 receptor Antibody, clone N331/19

  • 产品介绍
  • merck millipore,默克密理博,MABN463,Anti-Dopamine D3 receptor Antibody, clone N331/19

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, RICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN463
    描述 Anti-Dopamine D3 receptor Antibody, clone N331/19
    Alternate Names
    • Dopamine D3 receptor
    • D(3) dopamine receptor
    背景信息 Dopamine is a widely distributed neurotransmitter produced by hydroxylation of L-tyrosine, followed by decarboxylation with DOPA decarboxylase. Dopamine exerts its actions by interacting with multiple classes of dopamine receptors that belong to the family of G protein-coupled receptors. Thus far five dopamine receptor subtypes have been reported that are classified into two main families based on their sequence and similarity in signal role. The D1-like dopamine receptors include the dopamine receptors D1 and D5. Binding of dopamine to these receptors leads to the activation of adenylyl cyclase, via a Gs protein, leading to increased cAMP production. The dopamine D2-like receptor group consists of D2, D3, and D4 receptors, which are coupled to Gi/o proteins and act by inhibiting adenylyl cyclase activity. D3 receptor subtype was first cloned and characterized by Sokoloff et al in 1990 (Nature 347, pp 146-151). D3 receptor coupling to various signal transduction mechanisms usually mimic those of D2 receptors, however, their cerebral distribution is very different. Highest expression of D3 receptors is found in ventral striatum in human brain. Dopamine D3 receptor represents a potential target for development of drugs to treat various neuropsychiatric and neurological disorders such as schizophrenia, Parkinson’s disease, drugs of abuse.
    产品信息
    格式 Purified
    控制
    • Rat thalamus tissue
    演示 Purified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Dopamine D3 receptor antibody is validated for use in IHC & ICC for the detection of the Dopamine D3 receptor protein.
    主要应用
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 recpetor in rat cerebral cortex tissue.
    生物信息
    免疫原品种 Recombinant protein corresponding to human Dopamine D3 receptor.
    克隆 N331/19
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 HumanRat
    Species Reactivity Note Demonstrated to react with Rat and Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000787
    基因符号
    • DRD3
    纯化方法 Protein G purified
    UniProt编号
    • P35462
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in rat thalamus tissue.

    Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 receptor in rat thalamus tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN463,Anti-Dopamine D3 receptor Antibody, clone N331/19

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下一件merck millipore产品：merck millipore,默克密理博,AB9322,Anti-Serotonin Transporter Antibody


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