merck millipore,默克密理愽
  • merck millipore,默克密理博,252801,DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

  • merck millipore,默克密理博,252801,DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

    产品名称：DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem
    产品型号：252801
    The DGAT-1 Inhibitor, A 922500, also referenced under CAS 959122-11-3, controls the biological activity of DGAT-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,252801,DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,252801,DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₆H₂₄N₂O₄959122-11-3
    描述
    概述 An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
    产品目录编号 252801
    品牌系列 Calbiochem®
    参考
    参考 King, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
    产品信息
    CAS号 959122-11-3
    形式 Light yellow solid
    Hill配方 C₂₆H₂₄N₂O₄
    化学配方 C₂₆H₂₄N₂O₄
    Molar Mass 428.48
    结构配方图像
    生物信息
    纯度 >95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,252801,DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

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