merck millipore,默克密理愽
  • merck millipore,默克密理博,05-655,Anti-p21/WAF1/Cip1 Antibody, clone CP74

  • merck millipore,默克密理博,05-655,Anti-p21/WAF1/Cip1 Antibody, clone CP74

    产品名称：Anti-p21/WAF1/Cip1 Antibody, clone CP74
    产品型号：05-655
    Anti-p21/WAF1/Cip1 Antibody, clone CP74 is a high quality Mouse Monoclonal Antibody for the detection of p21/WAF1/Cip1 & has been validated in WB.

    merck millipore,默克密理博,05-655,Anti-p21/WAF1/Cip1 Antibody, clone CP74

  • 产品介绍
  • merck millipore,默克密理博,05-655,Anti-p21/WAF1/Cip1 Antibody, clone CP74

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-655
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-p21/WAF1/Cip1 Antibody, clone CP74
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-p21/WAF1/Cip1 Antibody, clone CP74 is a high quality Mouse Monoclonal Antibody for the detection of p21/WAF1/Cip1 & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant full-length human Cip1 with an N-terminal histidine tag; epitope corresponds to amino acids 1-80 of full-length human Cip1
    克隆 clone CP74
    宿主 Mouse
    特异性 Cip1
    同种型 IgG2bκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000389
    Entrez基因汇总 This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
    基因符号
    • CAP20
    • CDKN1A
    • MDA-6
    • SDI1
    • MDA6
    • p21
    • p21CIP1
    • PIC1
    • CIP1
    • P21
    • CDKN1
    • WAF1
    纯化方法 Protein G purfied
    UniProt编号
    • P38936
    UniProt汇总 FUNCTION: SwissProt: P38936 # May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
    SIZE: 164 amino acids; 18119 Da
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
    TISSUE SPECIFICITY: Expressed in all adult human tissues, with 5- fold lower levels observed in the brain.
    PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.
    SIMILARITY: SwissProt: P38936 ## Belongs to the CDI family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on nuclear extract from HeLa cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-655,Anti-p21/WAF1/Cip1 Antibody, clone CP74

上一件merck millipore产品：merck millipore,默克密理博,MAB8257,Anti-Influenza A Antibody, nucleoprotein, clone A1
下一件merck millipore产品：merck millipore,默克密理博,HTS111M,ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT6 Serotonin Receptor


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