merck millipore,默克密理博,234490,PD 153035 - CAS 153436-54-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,234490,PD 153035 - CAS 153436-54-5 - Calbiochem

经验配方	CAS号
C₁₆H₁₄BrN₃O₂	153436-54-5

描述
概述	An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; K_i = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
产品目录编号	234490
品牌系列	Calbiochem®
同义词	AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32

参考
参考	Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093.

产品信息
CAS号	153436-54-5
具有ATP竞争性	Y
声明	Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
形式	White solid
Hill配方	C₁₆H₁₄BrN₃O₂
化学配方	C₁₆H₁₄BrN₃O₂
Molar Mass	360.2
可逆	Y
结构配方图像

生物信息
主靶	EGFR
主靶IC₅₀	25 pM
主靶K_i	6 pM against epidermal growth factor receptor (EGFR)
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

merck millipore,默克密理博,234490,PD 153035 - CAS 153436-54-5 - Calbiochem

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