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merck millipore,默克密理博,239823,CXCR3 Agonist, PS372424 - Calbiochem
产品名称：CXCR3 Agonist, PS372424 - Calbiochem
产品型号：239823
The CXCR3 Agonist, PS372424 controls the biological activity of CXCR3. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,239823,CXCR3 Agonist, PS372424 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₃H₄₄N₆O₄ • 3H₂O 描述 概述 A peptidomimetic derivative containing tetrahydroisoquinoline-arginine motif that aligns with a Pro-Arg motif of CXCL10. Acts as a highly specific agonist of human CXCR3 (EC50 = 1.1 mM, competitive CXCL10 binding IC50 = 42 nM). Does not affect murine CXCR3. Induces a long-lasting internalization of about 87% of cell-surface CXCR3 within 30 min. Effectively stimulates T-cell migration (~ 50 nM) and blocks the migration of activated T cells towards CXCL11, CXCL12, and CCL5. Also reduces the migration of activated T cells towards rheumatoid arthritis synovial fibroblasts (RASF). Shown to induce phosphorylation of ERK with similar potency and kinetics as CXCL11. Also shown to block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice. 产品目录编号 239823 品牌系列 Calbiochem®
同义词 (S)-N-((S)-1-((cyclohexylmethyl)amino)-5-guanidino-1-oxopentan-2-yl)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, Chemokine (C-X-C motif) Receptor 3 Agonist 参考 参考 O'Boyle, G., et al. 2012, PNAS. 109, 4598.
Stroke, I. L., et al. 2006, Biochem Biophys Res Comm. 349, 221.产品信息 形式 White powder 配方 Supplied as a trifluoroacetate salt. Hill配方 C₃₃H₄₄N₆O₄ • 3H₂O 化学配方 C₃₃H₄₄N₆O₄ • 3H₂O Molar Mass 588.7 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,MABN1033,Anti-MGEA5 Antibody, clone EPR7154(B), rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,437692,α-Lipoic Acid - CAS 1077-28-7 - Calbiochem
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