- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,239820,CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem
产品名称：CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem
产品型号：239820
The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,239820,CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₈H₅₄N₈ • 8HCl 155148-31-5 描述 概述 A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC50 = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca2+ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC50 ≤200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC50 = 6.48 and 11.8 nM, in the presence and absence of 10 µM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9. Also available as a 50 mM solution in H2O (Cat. No. 239825). 产品目录编号 239820 品牌系列 Calbiochem®
同义词 1,1ʹ-(1,4-Phenylenebis(methylene))-bis-1,4,8,11-tetraazacyclotetradecane, 8HCl, JM3100 参考 参考 Kalatskaya, I., et al. 2009. Mol. Pharmacol. 77, 1240.
Pitchford, S.C., et al. 2009. Cell Stem Cell 4, 62.
De Clercq, E. 2009. Biochem. Pharmacol. , 1655.
Thoma, G., et al. 2008. J. Med. Chem. 51, 7915.
De Clercq, E. 2000. Mol. Pharmacol. 57, 833.产品信息 CAS号 155148-31-5 形式 Off-white solid Hill配方 C₂₈H₅₄N₈ • 8HCl 化学配方 C₂₈H₅₄N₈ • 8HCl Molar Mass 794.5 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,AB2500,Anti-Amyloid beta A4 protein Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB1599,Anti-Phosphotyrosine Antibody
相关产品
merck millipore,默克密理博,189405,Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
merck millipore,默克密理博,AP132-K,Goat Anti-Rabbit IgG, Affinity Purified (1mg)
merck millipore,默克密理博,03-185,Histone H2B human recombinant
merck millipore,默克密理博,14-510M,Lyn Protein, active, 250 µg
merck millipore,默克密理博,AB2500,Anti-Amyloid beta A4 protein Antibody
merck millipore,默克密理博,AB1599,Anti-Phosphotyrosine Antibody
merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody
merck millipore,默克密理博,AP1181,Anti-TLR7 Mouse mAb (2C9)
merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23
merck millipore,默克密理博,MABE162,Anti-IGHMBP2 Antibody, clone11-24