merck millipore,默克密理愽
  • merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

  • merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

    产品名称：Anti-BRCA2 Antibody, clone 5.23
    产品型号：05-666
    Detect BRCA2 with Anti-BRCA2 Antibody, clone 5.23 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.

    merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

  • 产品介绍
  • merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-666
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-BRCA2 Antibody, clone 5.23
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
    应用
    应用 Detect BRCA2 with Anti-BRCA2 Antibody, clone 5.23 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 GST fusion protein to residues 2959-3418 of human BRCA2 protein
    克隆 clone 5.23
    宿主 Mouse
    特异性 BRCA2
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000059
    Entrez基因汇总 Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintainance of genome stability, specificallythe homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
    基因符号
    • FANCD
    • BRCA2
    • FACD
    • FANCB
    • FAD1
    • FAD
    • FANCD1
    • BRCC2
    • OTTHUMP00000042401
    纯化方法 Protein G chromatography
    UniProt编号
    • P51587
    UniProt汇总 FUNCTION: SwissProt: P51587 # Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation.
    SIZE: 3418 amino acids; 384225 Da
    SUBUNIT: Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoints functions. Interacts with WDR16.
    TISSUE SPECIFICITY: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
    PTM: Phosphorylated by ATM upon irradiation-induced DNA damage.
    DISEASE: SwissProt: P51587 # Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) [MIM:600185, 114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. Mutations in BRCA2 are thought to be responsible for some inherited breast cancer. It is linked with male breast cancer. & Defects in BRCA2 are the cause of Fanconi anemia complementation group D type 1 (FANCD1) [MIM:605724]. Fanconi anemia [MIM:227650] is an autosomal recessive disorder affecting all bone marrow elements and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes.
    SIMILARITY: SwissProt: P51587 ## Contains 8 BRCA2 repeats.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on in HeLa nuclear extract
    销售限制 Due to license agreement restrictions, this product cannot be purchased for resale.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at 2-8°C. Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

上一件merck millipore产品：merck millipore,默克密理博,AP1181,Anti-TLR7 Mouse mAb (2C9)
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