merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody

  • merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody

    产品名称：Anti-IL-12R-beta-1 Antibody
    产品型号：06-1089
    Detect IL-12R-beta-1 using this Anti-IL-12R-beta-1 Antibody validated for use in WB, IH.

    merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1089
    描述 Anti-IL-12R-beta-1 Antibody
    Alternate Names
    • IL-12 receptor subunit beta-1
    • interleukin 12 receptor, beta 1
    • interleukin-12 receptor beta-1 chain
    • IL-12R-beta-1
    • IL-12R subunit beta-1
    • interleukin-12 receptor subunit beta-1
    • IL-12 receptor beta component
    • CD212 antigen
    背景信息 Interleukin 12 receptor beta 1 (IL-12R-beta-1) is a low affinity receptor for IL-12. IL-12R-beta-1 is thought to combine with IL-12R-beta-2 to form a high affinity receptor for IL-12. It can also associate with IL-23R to form the receptor for Interleukin 23. IL-12R-beta-1, in the IL-23R form, may be involved in IL23 signal transduction through the launch of the Jak-Stat signaling cascade and is also thought to play a role in IL-12 transduction. IL-12R-beta-1 deficiency is often linked to severe tuberculosis.
    产品信息
    格式 Affinity Purified
    控制
    • Jurkat cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect IL-12R-beta-1 using this Anti-IL-12R-beta-1 Antibody validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected IL-12R-beta-1 in normal human spleen tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human IL-12R-beta-1 at the cytoplasmic domain.
    表位 Cytoplasmic domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes IL-12R-beta-1 at the cytoplasmic domain.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005526
    Entrez基因汇总 The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq].
    基因符号
    • IL12R
    • IL-12RB1
    • CD212
    • IL-12R-BETA1
    • IL12RB
    • IL12RB1
    纯化方法 Affinity purified
    UniProt编号
    • P42701
    UniProt汇总 FUNCTION: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Ref.9

    SUBUNIT STRUCTURE: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

    The box 1 motif is required for JAK interaction and/or activation.

    INVOLVEMENT IN DISEASE: Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

    SEQUENCE SIMLARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.

    Contains 5 fibronectin type-III domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in Jurkat cell lysate.

    Western Blot Analysis: 0.025 µg/mL of this antibody detected IL-12R-beta-1 on 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1089,Anti-IL-12R-beta-1 Antibody

上一件merck millipore产品：merck millipore,默克密理博,AB1599,Anti-Phosphotyrosine Antibody
下一件merck millipore产品：merck millipore,默克密理博,AP1181,Anti-TLR7 Mouse mAb (2C9)


相关产品

merck millipore,默克密理博,03-185,Histone H2B human recombinant merck millipore,默克密理博,03-185,Histone H2B human recombinant

merck millipore,默克密理博,14-510M,Lyn Protein, active, 250 µg merck millipore,默克密理博,14-510M,Lyn Protein, active, 250 µg

merck millipore,默克密理博,AB2500,Anti-Amyloid beta A4 protein Antibody merck millipore,默克密理博,AB2500,Anti-Amyloid beta A4 protein Antibody

merck millipore,默克密理博,239820,CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem merck millipore,默克密理博,239820,CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem

merck millipore,默克密理博,AB1599,Anti-Phosphotyrosine Antibody merck millipore,默克密理博,AB1599,Anti-Phosphotyrosine Antibody

merck millipore,默克密理博,AP1181,Anti-TLR7 Mouse mAb (2C9) merck millipore,默克密理博,AP1181,Anti-TLR7 Mouse mAb (2C9)

merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23 merck millipore,默克密理博,05-666,Anti-BRCA2 Antibody, clone 5.23

merck millipore,默克密理博,MABE162,Anti-IGHMBP2 Antibody, clone11-24 merck millipore,默克密理博,MABE162,Anti-IGHMBP2 Antibody, clone11-24

merck millipore,默克密理博,215911,Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem merck millipore,默克密理博,215911,Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

merck millipore,默克密理博,14-761,Txk Protein, active, 10 µg merck millipore,默克密理博,14-761,Txk Protein, active, 10 µg


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部