merck millipore,默克密理愽
  • merck millipore,默克密理博,23-026,SCF-TrCP1 Protein Complex, Active, 10 µg

  • merck millipore,默克密理博,23-026,SCF-TrCP1 Protein Complex, Active, 10 µg

    产品名称：SCF-TrCP1 Protein Complex, Active, 10 µg
    产品型号：23-026
    Active complex of four (4) recombinant human enzymes: full length Skp1, full length Cul1, full length Rbx1, & βTrCP1 (amino acids 53-end). For use in Enzyme Assays. Functions as an E3 ligase in ubiqui More>>

    merck millipore,默克密理博,23-026,SCF-TrCP1 Protein Complex, Active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,23-026,SCF-TrCP1 Protein Complex, Active, 10 µg

    重要规格表

    主要应用 品种 级联部件
    EAHumanE3
    描述
    产品目录编号 23-026
    品牌系列 Upstate
    商名
    • Upstate
    描述 SCF-TrCP1 Protein Complex, Active, 10 µg
    长描述 Complex of N-terminal GST-tagged, recombinant human βTrCP1 amino acids 53-end, N-terminal GST-tagged, recombinant human Skp1 full length, N-terminal 6His-tagged, recombinant human Cul1 full length and untagged recombinant human Rbx1 full length, co-expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.
    Alternate Names
    • SCF-bTrCP1
    • SCF-β-TrCP
    • SCF<sup>FWD1</sup>
    背景信息 The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFβTrCP1 mediates the ubiquitination and subsequent proteasomal degradation of a variety of proteins involved in various cellular processes, these include IκBα, an inhibitor of the transcription factor NFκB and β-catenin which is involved in the Wnt signalling pathway. A number of cancers, including those in breast, colon and pancreatic tissue have been associated with the deregulation of SCFβTrCP1
    应用
    应用 Active complex of four (4) recombinant human enzymes: full length Skp1, full length Cul1, full length Rbx1, & βTrCP1 (amino acids 53-end). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    级联部件 E3
    Entrez基因编号
    • NM_014248 (Rbx1) (GenBank Number)
    • NM_033637 (βTrCP1, contains the amino acid substitution E353D with reference to GenBank NM_033637) (GenBank Number)
    • NM_170679 (Skp1) (GenBank Number)
    • NM_003592 (Cul1) (GenBank Number)
    纯化方法 Purified using glutathione sepharose.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,23-026,SCF-TrCP1 Protein Complex, Active, 10 µg

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