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merck millipore,默克密理博,220486,Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
产品名称：Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
产品型号：220486
The Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>
merck millipore,默克密理博,220486,Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₄ClN₃O₂ 516480-79-8 描述 概述 A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491). 产品目录编号 220486 品牌系列 Calbiochem®
同义词 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide 参考 参考 Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873. 产品信息 CAS号 516480-79-8 具有ATP竞争性 Y 形式 Pale yellow solid Hill配方 C₂₀H₁₄ClN₃O₂ 化学配方 C₂₀H₁₄ClN₃O₂ Molar Mass 363.8 可逆 Y 结构配方图像 生物信息 主靶 Chk2 主靶IC50 15 nM; Ki = 37 nM inhibiting Chk2; EC50 = 3 µM and 7.6 µM in rescuing both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis 主靶Ki 37 nM inhibiting Chk2 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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