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merck millipore,默克密理博,567370,Smac-N7 Peptide
产品名称：Smac-N7 Peptide
产品型号：567370
A peptide that contains the N-terminal seven residues of Smac (Second Mitochondria-derived Activator of Caspases, also known as DIABLO) and promotes procaspase-3 activation at around 10 µM.
merck millipore,默克密理博,567370,Smac-N7 Peptide
- 产品介绍
重要规格表
经验配方 C₃₃H₅₉N₉O₉ 描述 概述 A peptide that contains the N-terminal seven residues of Smac (Second Mitochondria-derived Activator of Caspases, also known as DIABLO) and promotes procaspase-3 activation at around 10 µM. Reported to bind to the BIR2 and BIR3 (baculovirus IAP repeat) domains of XIAP (X-linked inhibitor of apoptosis proteins) with a Kd ~800 nM. Promotes the catalytic activity of caspase-9 in the presence of XIAP, suggesting that Smac competes with caspase-9 for binding to the same pocket on the surface of XIAP. 产品目录编号 567370 品牌系列 Calbiochem®
同义词 H-AVPIAQK-OH 参考 参考 Srinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.产品信息 具有ATP竞争性 N 形式 White lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₃₃H₅₉N₉O₉ 化学配方 C₃₃H₅₉N₉O₉ Molar Mass 725.9 肽序列 H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH 可逆 N 生物信息 主靶 Promotes the catalytic activity of caspase-9 in the presence of XIAP 主靶IC50 Kd ~800 nM in binding to the BIR2 and BIR3 (baculovirus IAP repeat) domains of XIAP (X-linked inhibitor of apoptosis proteins) 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO or H₂O 肽序列 H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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