merck millipore,默克密理愽
  • merck millipore,默克密理博,219489,Ceramide Kinase Inhibitor, K1

  • merck millipore,默克密理博,219489,Ceramide Kinase Inhibitor, K1

    产品名称：Ceramide Kinase Inhibitor, K1
    产品型号：219489
    The Ceramide Kinase Inhibitor, K1, also referenced under CAS 1258005-85-4, controls the biological activity of Ceramide Kinase. This small molecule/inhibitor is primarily used for Cell Signaling appli More>>

    merck millipore,默克密理博,219489,Ceramide Kinase Inhibitor, K1

  • 产品介绍
  • merck millipore,默克密理博,219489,Ceramide Kinase Inhibitor, K1

    重要规格表

    经验配方 CAS号
    C₂₁H₂₈O₄1258005-85-4
    描述
    概述 A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 > 100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.
    产品目录编号 219489
    品牌系列 Calbiochem®
    同义词 F-12509A Cyclic Product K1
    参考
    参考 Kim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
    Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
    Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
    产品信息
    CAS号 1258005-85-4
    声明 Sold for research purposes only, pursuant to an agreement with Merck Japan.
    形式 Yellow powder
    Hill配方 C₂₁H₂₈O₄
    化学配方 C₂₁H₂₈O₄
    Molar Mass 344.4
    结构配方图像
    生物信息
    纯度 ≥95% by NMR (mixture of enantiomers)
    理化信息
    溶解度 EtOH
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219489,Ceramide Kinase Inhibitor, K1

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