merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1550,Anti-SC-35 Antibody, clone 1SC-4F11

  • merck millipore,默克密理博,04-1550,Anti-SC-35 Antibody, clone 1SC-4F11

    产品名称：Anti-SC-35 Antibody, clone 1SC-4F11
    产品型号：04-1550
    Anti-SC-35 Antibody, clone 1SC-4F11 is a Mouse Monoclonal Antibody for detection of SC-35 also known as Protein PR264, Splicing factor SC35 & has been validated in WB, ICC.

    merck millipore,默克密理博,04-1550,Anti-SC-35 Antibody, clone 1SC-4F11

  • 产品介绍
  • merck millipore,默克密理博,04-1550,Anti-SC-35 Antibody, clone 1SC-4F11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1550
    描述 Anti-SC-35 Antibody, clone 1SC-4F11
    Alternate Names
    • splicing factor, arginine/serine-rich 2
    • Protein PR264
    • Splicing component, 35 kDa
    • Splicing factor SC35
    背景信息 SC-35 is also known as Splicing factor SC35 and Splicing factor, arginine/serine-rich 2. This protein is encoded by the SFRS2 gene and is a member of the splicing factor SR family. SC-35 is involved in pre-mRNA splicing and is found in bodies in the nucleus that are highly enriched in poly(A) RNA. These nuclear bodies are referred to as speckles, SC 35 domains, or splicing factor compartments (SFCs). The purpose of these bodies is still widely disputed. Speckles correspond largely to, if not entirely to, ultra structures called inter-chromatin granule clusters (IGCs). SC3-35 is required for pre-mRNA splicing events and is highly involved in spliceosomal interaction and assembly. SC-35 is necessary for assembly of the ATP-dependent splicing complex. It is also necessary for the ATP-dependent communication between pre-mRNA and U1 and U2 snRNPs.
    产品信息
    格式 Ascites
    控制
    • A431 cell lysate
    演示 Unpurified mouse monoclonal IgG1κ preservative-free ascites.
    应用
    应用 Anti-SC-35 Antibody, clone 1SC-4F11 is a Mouse Monoclonal Antibody for detection of SC-35 also known as Protein PR264, Splicing factor SC35 & has been validated in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected SC35 in NIH/3T3 cells.
    生物信息
    免疫原品种 Ovalbumin-conjugated linear peptide corresponding to human SC35.
    表位 Unknown
    克隆 clone 1SC-4F11
    宿主 Mouse
    特异性 This antibody recognizes SC35.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_003007.2
    基因符号
    • SRp30b
    • SFRS2
    • PR264
    • SC-35
    • SC35
    • SFRS2A
    纯化方法 Unpurified
    UniProt编号
    • Q01130
    UniProt汇总 FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway.

    SUBUNIT STRUCTURE: In vitro, binds SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SFRS2IP.

    SUBCELLULAR LOCATION: Nucleus.

    PTM: Extensively phosphorylated on serine residues in the RS domain.

    SEQUENCE SIMLARITIES: Belongs to the splicing factor SR family.

    Contains 1 RRM (RNA recognition motif) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected Sc35 on 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1550,Anti-SC-35 Antibody, clone 1SC-4F11

上一件merck millipore产品：merck millipore,默克密理博,AP113A-K,Goat anti-Human IgG, Fc, Alkaline Phosphatase conjugate (1mg)
下一件merck millipore产品：merck millipore,默克密理博,05-1320,Anti-EED Antibody, clone AA19


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