merck millipore,默克密理愽
  • merck millipore,默克密理博,09-809,Anti-JMJD2A Antibody

  • merck millipore,默克密理博,09-809,Anti-JMJD2A Antibody

    产品名称：Anti-JMJD2A Antibody
    产品型号：09-809
    Anti-JMJD2A Antibody is a rabbit polyclonal antibody for detection of JMJD2A also known as lysine (K)-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A & has been valida More>>

    merck millipore,默克密理博,09-809,Anti-JMJD2A Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-809,Anti-JMJD2A Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rhesus Macaque, H, M, ChpChIP, WB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 09-809
    描述 Anti-JMJD2A Antibody
    Alternate Names
    • Jumonji domain-containing protein 2A
    • JMJD
    • lysine (K)-specific demethylase 4A
    • JmjC domain-containing histone demethylation protein 3A
    • jumonji domain containing 2A
    • jumonji C domain-containing histone demethylase 3A
    • jumonji domain containing 2
    • lysine-specific demethylase 4A
    背景信息 Jumonji domain-containing protein 2A (JMJD2A) is a nuclear and cytoplasmic member of the JMJD2 family, a group of proteins characterized as containing a JmjC domain, a JmjN domain, two PHD-type zinc finger domains, and 2 Tudor domains. Little is known about the function for most of these domains; however, they are believed to be involved in transcriptional regulation. JMJD2A functions as a histone demethylase with specific activity against trimethylated Histone H3 Lysine residues Lys-9 and Lys-36. It has no effect on any other lysine residues, or on mono- and dimethylated Lys-9 and Lys-36. The demethylation of these residues induces the production of succinate and formaldehyde. Studies have shown JMJD2A to recruit NCOR1 and histone deacetylases, causing the respective transcriptional repression of E2F- and ASCL2 responsive promoters. JMJD2A is ubiquitously expressed in human cell lines and tissues.
    产品信息
    格式 Affinity Purified
    控制
    • U2OS nuclear extract
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-JMJD2A Antibody is a rabbit polyclonal antibody for detection of JMJD2A also known as lysine (K)-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A & has been validated in WB, ICC.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western Blot Analysis: 1 µg/mL from a previous lot detected JMJD2A in 10 µg of human testis tissue lysate.

    Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected JMJD2A in A431 cells.

    Chromatin Immunoprecipitation (ChIP) Analysis: A previous lot was used by an independent laboratory in ChIP on mouse embyronic cells (David Vetrie, University of Glasgow, Glasgow).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human JMJD2A.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Rhesus MacaqueHumanMouseChimpanzee
    Species Reactivity Note Demonstrated to react with human and mouse.
    Predicted to react with chimpanzee and rhesus macaque based on 100% sequence homology.
    Other homologies: Rat (75% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_055478.2
    Entrez基因汇总 This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq].
    基因符号
    • KDM4A
    • JHDM3A
    • JMJD2
    • JMJD2A
    纯化方法 Affinity Purified
    UniProt编号
    • O75164
    UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

    COFACTOR: Binds 1 Fe2+ ion per subunit.

    SUBUNIT STRUCTURE: Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein.

    SUBCELLULAR LOCATION: Nucleus

    TISSUE SPECIFICITY: Ubiquitous.

    DOMAIN: The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are able to bind trimethylated histone H3 'Lys-4', trimethylated histone H3 'Lys-9', di- and trimethylated H4 'Lys-20'.

    SEQUENCE SIMILARITIES: Belongs to the JHDM3 histone demethylase family.

    Contains 1 JmjC domain.

    Contains 1 JmjN domain.

    Contains 2 PHD-type zinc fingers.

    Contains 2 Tudor domains.

    SEQUENCE CAUTION: The sequence BAA31652.2 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in U2OS nuclear extract.

    Western Blot Analysis: 1 µg/mL of this antibody detected JMJD2A in 10 µg of U2OS nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,09-809,Anti-JMJD2A Antibody

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