merck millipore,默克密理愽
  • merck millipore,默克密理博,208711,Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem

  • merck millipore,默克密理博,208711,Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem

    产品名称：Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem
    产品型号：208711
    The Ca2+/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca2+/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation More>>

    merck millipore,默克密理博,208711,Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,208711,Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem

    重要规格表

    经验配方
    C₁₄₆H₂₅₄N₄₆O₃₉S₃
    描述
    概述 A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site (IC50 = 2 µM).
    产品目录编号 208711
    品牌系列 Calbiochem®
    同义词 CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
    参考
    参考 Waxham, M.N., et al. 1993. Biochemistry 32, 2923.
    Waxham, M.N., et al. 1993. Brain Res. 609, 1.
    Fukunaga, K., et al. 1990. J. Neurochem. 54, 103.
    Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
    Colbran, R.J., et al. 1988. J. Biol. Chem. 263, 18145.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₄₆H₂₅₄N₄₆O₃₉S₃
    化学配方 C₁₄₆H₂₅₄N₄₆O₃₉S₃
    Molar Mass 3374.1
    吸湿 Hygroscopic
    肽序列 H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
    可逆 N
    基于肽含量售出 Yes
    生物信息
    主靶 CaM Kinase II
    主靶IC50 80nM
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 H₂O
    肽含量 Yes
    肽序列 H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,208711,Ca2+/Calmodulin Kinase II Inhibitor 281-309 - Calbiochem

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