merck millipore,默克密理博,203900,Bufalin - CAS 465-21-4

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merck millipore,默克密理博,203900,Bufalin - CAS 465-21-4 - Calbiochem
产品名称：Bufalin - CAS 465-21-4 - Calbiochem
产品型号：203900
A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC₅₀ = 1.4 nM).

merck millipore,默克密理博,203900,Bufalin - CAS 465-21-4 - Calbiochem

产品介绍

merck millipore,默克密理博,203900,Bufalin - CAS 465-21-4 - Calbiochem

重要规格表

经验配方	CAS号
C₂₄H₃₄O₄	465-21-4

描述
概述	A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na⁺,K⁺-ATPase activity (IC₅₀ = 1.4 nM). Induces apoptosis in various human cell lines such as leukemia HL-60 and U937 cells by altering the expression of apoptosis-related genes. Reported to stimulate the activities of p21 activated kinase (PAK) and c-Jun Kinase (JNK) in leukemic cell lines. Induces a transient increase in the expression of Tiam1 mRNA in U937 cell lines (~100 nM). Bufalin also down-regulates gene expression of the intracellular signaling protein 14-3-3 in rat lens, probably a consequence of Na⁺,K⁺-ATPase inhibition. Reduces the level of topoisomerase II in human leukemia cells.
产品目录编号	203900
品牌系列	Calbiochem®
同义词	5β, 20(22)-Bufadienolide-3β, 14-diol

参考
参考	Kurosawa, M., et al. 2000. Am. J. Physiol. 278, C500. Kawazoe, N., et al. 1999. Oncogene 18, 2413. McGowan, M.H., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1559. Watabe, M., et al. 1998. Oncogene 16, 779. Hashimoto, S., et al. 1997. Leuk. Res. 21, 875. Morris, J.F., et al. 1997. Comp. Biochem. Physiol. A Physiol. 118, 599. Brownlee, A.A., et al. 1990. Clin. Sci. 78, 169.

参考

Kurosawa, M., et al. 2000. Am. J. Physiol. 278, C500.
Kawazoe, N., et al. 1999. Oncogene 18, 2413.
McGowan, M.H., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1559.
Watabe, M., et al. 1998. Oncogene 16, 779.
Hashimoto, S., et al. 1997. Leuk. Res. 21, 875.
Morris, J.F., et al. 1997. Comp. Biochem. Physiol. A Physiol. 118, 599.
Brownlee, A.A., et al. 1990. Clin. Sci. 78, 169.

产品信息
CAS号	465-21-4
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₂₄H₃₄O₄
化学配方	C₂₄H₃₄O₄
Molar Mass	386.5
可逆	N
结构配方图像

生物信息
主靶	Ouabain-sensitive Na+,K+-ATPase activity
主靶IC₅₀	1.4 nM against ouabain-sensitive Na+,K+-ATPase activity
纯度	≥98% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or warm EtOH

GHS安全信息
RTECS	EI2962500

安全信息
R相	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.