merck millipore,默克密理愽
  • merck millipore,默克密理博,189512,Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

  • merck millipore,默克密理博,189512,Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

    产品名称：Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem
    产品型号：189512
    The Autotaxin Inhibitor III, PF-8380, also referenced under CAS 1144035-53-9, controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Membrane applications.

    merck millipore,默克密理博,189512,Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,189512,Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₁Cl₂N₃O₅1144035-53-9
    描述
    概述 An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30 mg/kg, p.o.).
    产品目录编号 189512
    品牌系列 Calbiochem®
    同义词 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one, Atx Inhibitor III, PF-8380
    参考
    参考 Gierse, J., et al. 2010. J. Pharmacol. Exp. Ther. 334, 310.
    产品信息
    CAS号 1144035-53-9
    形式 Tan powder
    Hill配方 C₂₂H₂₁Cl₂N₃O₅
    化学配方 C₂₂H₂₁Cl₂N₃O₅
    Molar Mass 478.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,189512,Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-530,B-Raf (δ1-415) Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,8590-OP,OmniPur Sucrose Solution, 20% W/V - Calbiochem


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