merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB10003,Anti-HECTH9 Antibody, clone AX81

  • merck millipore,默克密理博,MAB10003,Anti-HECTH9 Antibody, clone AX81

    产品名称：Anti-HECTH9 Antibody, clone AX81
    产品型号：MAB10003
    Detect HECTH9 using this Anti-HECTH9 Antibody, clone AX81 validated for use in IC.

    merck millipore,默克密理博,MAB10003,Anti-HECTH9 Antibody, clone AX81

  • 产品介绍
  • merck millipore,默克密理博,MAB10003,Anti-HECTH9 Antibody, clone AX81

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB10003
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-HECTH9 Antibody, clone AX81
    Alternate Names
    • E3
    • ARF binding protein 1
    • Mcl-1 ubiquitin ligase E3
    • WWE domain containing 1
    • UBA
    • HECT
    背景信息 Hecth9 is a E3 ubiquitin ligase and is believed to be involved in the ubiquitination of myc. The HectH9-mediated ubiquitination of Myc is required for transactivation of multiple target genes, recruitment of the coactivator p300, and induction of cell proliferation by Myc.
    产品信息
    格式 Ascites
    演示 Liquid containing 0.1% sodium azide.
    应用
    应用 Detect HECTH9 using this Anti-HECTH9 Antibody, clone AX81 validated for use in IC.
    主要应用
    • Immunocytochemistry
    应用说明 Western Blot: antibody reacts with HectH9, approximately 450 kDa.
    Immunocytochemistry: reacts with methanol fixed cells at 1:200.
    Immunoprecipitation: immunoprecipitates endogenous HectH9 from HeLa cell extracts, {Adhikary, S. 2005}.
    生物信息
    免疫原品种 Synthetic peptide cooresponding to amino acids 2530-2596 of human HectH9 {Adhikary, S. et al, 2005}.
    克隆 AX81
    宿主 Mouse
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_031407.3
    基因符号
    • EC 6.3.2.-
    • HUWE1
    • KIAA1578
    • KIAA0312
    • MULE
    • Mule
    • UREB1
    • LASU1
    • 5430439H10Rik
    • URE-B1
    • OTTHUMP00000061860
    • E3(Histone)
    • Ib772
    • ARF-BP1
    • HSPC272
    • HECTH9
    纯化方法 Ascites
    UniProt编号
    • Q7Z6Z7
    UniProt汇总 FUNCTION: SwissProt: Q7Z6Z7 # E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Also ubiquitinates the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene.
    SIZE: 4374 amino acids; 481891 Da
    SUBUNIT: Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity.
    SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Predominantly cytosolic or perinuclear in some colorectal carcinoma cells.
    TISSUE SPECIFICITY: Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.
    DOMAIN:SwissProt: Q7Z6Z7 The HECT domain mediates inhibition of the transcriptional activity of p53.
    PTM: Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: Belongs to the TOM1/PTR1 family. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 1 UBA domain. & Contains 1 UIM (ubiquitin-interacting motif) repeat. & Contains 1 WWE domain.
    产品使用声明
    质量保证 Routinely evaluated by FMAT
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at 2-8°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB10003,Anti-HECTH9 Antibody, clone AX81

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