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品种反应性 主要应用 宿主 格式 抗体类型 R, H, Ma WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-356 品牌系列 Upstate
商名 - Upstate
描述 Anti-NR3A Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-NR3A Antibody is an antibody against NR3A for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 1098-1113 (SRKTELEEYQKTNRTC) of rat NR3A 宿主 Rabbit 特异性 NR3A 同种型 IgG 品种反应性 RatHumanMammals 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_133445.1
Entrez基因汇总 This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. 基因符号 - FLJ45414
- GRIN3A
- KIAA1973
- Glutamate
- NMDAR-L
- NR3A
纯化方法 Protein A chromatography UniProt编号 - Q8TCU5
UniProt汇总 FUNCTION: SwissProt: Q8TCU5 # NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
SIZE: 1115 amino acids; 125595 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).DEVELOPMENTAL STAGE: Expressed in fetal brain.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: Q8TCU5 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 质量保证 routinely evaluated by immunoblot in a rat brain microsomal protein preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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