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经验配方 C₁₉H₂₀N₄ 描述 概述 A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment. 产品目录编号 420294 品牌系列 Calbiochem®
同义词 N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine 参考 参考 Su, J.C., et al. 2009, Life Sci. 85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.产品信息 形式 Brown solid Hill配方 C₁₉H₂₀N₄ 化学配方 C₁₉H₂₀N₄ Molar Mass 304.39 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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