merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1408,Anti-Glucose Regulating Protein 94 (GRP94) Antibody

  • merck millipore,默克密理博,07-1408,Anti-Glucose Regulating Protein 94 (GRP94) Antibody

    产品名称：Anti-Glucose Regulating Protein 94 (GRP94) Antibody
    产品型号：07-1408
    Anti-Glucose Regulating Protein 94 (GRP94) Antibody detects level of Glucose Regulating Protein 94 (GRP94) & has been published & validated for use in WB & IC.

    merck millipore,默克密理博,07-1408,Anti-Glucose Regulating Protein 94 (GRP94) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1408,Anti-Glucose Regulating Protein 94 (GRP94) Antibody

    Replacement Information
    Replacement Information 07-1408 is a recommended replacement for AB3545.

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MkICC, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 07-1408
    Replaces AB3545
    描述 Anti-Glucose Regulating Protein 94 (GRP94) Antibody
    Alternate Names
    • Heat shock protein 90 kDa beta member
    • 94 kDa glucose-regulated protein 3
    • Endoplasmin precursor 3
    产品信息
    格式 Serum
    控制
    • Jurkat cell lysate
    演示 Rabbit polyclonal IgG serum in buffer containing 0.02% sodium azide.
    应用
    应用 Anti-Glucose Regulating Protein 94 (GRP94) Antibody detects level of Glucose Regulating Protein 94 (GRP94) & has been published & validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry:
    Rabbit anti-GRP94 from a previous lot detected localization of GRP94 (green) in HEK293 cells. Blue staining is DAPI which stains the nucleus of the cell. Previous lots of this antibody showed positive testing for immunocytochemistry on HeLa, COS7 and HEK293 cells.

    Optimal working dilutions must be determined by the end user

    Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet.
    生物信息
    免疫原品种 Peptide corresponding to an internal sequence from human GRP94.
    宿主 Rabbit
    特异性 Glucose regulating protein 94 (GRP94, Endoplasmin).
    同种型 IgG
    品种反应性 RatHumanMonkey
    Species Reactivity Note Human, rat and monkey. Other species not tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003299.1
    Entrez基因汇总 HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM].
    基因符号
    • ECGP
    • HSP90B1
    • GP96
    • GRP94
    • TRA1
    UniProt编号
    • P14625
    UniProt汇总 FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity (By similarity).
    SUBUNIT: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
    SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    PTM: Phosphorylated (By similarity).
    SIMILARITY: Belongs to the heat shock protein 90 family.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Jurkat lysates.

    Western Blot Analysis:
    1:500-1:1,500 dilution of this lot detected GRP94 on 10 μg of Jurkat lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C in undiluted aliquots from date of receipt.
    Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1408,Anti-Glucose Regulating Protein 94 (GRP94) Antibody

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