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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB1820 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Scribble Antibody Alternate Names - LAP4
- Scrib
背景信息 Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007). 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified in PBS containing with 0.05% NaN3. 应用 应用 This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble. 主要应用 - Western Blotting
应用说明 Suggested dilutions:
Western blot: 0.2 µg (1:2000)生物信息 免疫原品种 GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble 表位 PDZ2 domain of Scribble 克隆 7C6.D10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 PDZ2 domain of Scribble 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - AAL38976
基因符号 - SCRB1
- SCRIB
纯化方法 Protein G chromatography UniProt编号 - Q14160
UniProt汇总 FUNCTION: May be required for polarization of epithelia
SUBUNIT: Interacts through its PDZ domains with VANGL2. Interacts with UBE3A, HPV E6 and LPP.
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note: Localized to cell junctions
SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.产品使用声明 质量保证 Routinely evaluated by Western blot on HeLa cell lysates. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 1 year after date of receipt. 包装信息 数量 50 µg
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