merck millipore,默克密理愽
  • merck millipore,默克密理博,189406,Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

  • merck millipore,默克密理博,189406,Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

    产品名称：Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
    产品型号：189406
    The Aurora Kinase/Cdk Inhibitor, also referenced under CAS 443797-96-4, controls the biological activity of Aurora Kinase/Cdk. This small molecule/inhibitor is primarily used for Phosphorylation & Dep More>>

    merck millipore,默克密理博,189406,Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,189406,Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂F₂N₆O₃S • CH₃CN443797-96-4
    描述
    概述 A cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
    产品目录编号 189406
    品牌系列 Calbiochem®
    同义词 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
    参考
    参考 Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
    Lin R., et al. 2005. J. Med. Chem. 48, 4208.
    产品信息
    CAS号 443797-96-4
    具有ATP竞争性 Y
    形式 White solid
    Hill配方 C₁₅H₁₂F₂N₆O₃S • CH₃CN
    化学配方 C₁₅H₁₂F₂N₆O₃S • CH₃CN
    Molar Mass 435.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 Aurora Kinase/Cdk
    主靶IC50 11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,189406,Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

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