merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1

  • merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1

    产品名称：Anti-Integrin β4 Antibody, clone 3E1
    产品型号：MAB1964
    This Anti-Integrin β4 Antibody, clone 3E1 is validated for use in FC, IC, IH, IP for the detection of Integrin β4.

    merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1

  • 产品介绍
  • merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, FC, ICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1964
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin β4 Antibody, clone 3E1
    Alternate Names
    • CD104
    背景信息 Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.
    产品信息
    格式 Ascites
    控制
    • A431 cell lysate
    演示 UnPurified ascites containing no preservatives.
    应用
    应用 This Anti-Integrin β4 Antibody, clone 3E1 is validated for use in FC, IC, IH, IP for the detection of Integrin β4.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    • Immunocytochemistry
    应用说明 Stains human skin in immunofluorescence at approximately 1:200; acetone fixation required.

    Also suitable for use in immunoprecipitation and flow cytometric assays.

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 3E1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with Human beta4 integrin. The antigen is present on epithelial cells.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001005731.1
    • NM_000213.3
    • NM_001005619.1
    Entrez基因汇总 Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
    基因符号
    • GP150
    • ITGB4
    • CD104
    纯化方法 Unpurified
    UniProt编号
    • P16144
    UniProt汇总 FUNCTION: SwissProt: P16144 # Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
    SIZE: 1822 amino acids; 202151 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
    DOMAIN: SwissProt: P16144 The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
    DISEASE: SwissProt: P16144 # Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. & Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. This nonlethal form of junctional epidermolysis bullosa is characterized by life- long blistering of the skin, associated with hair and tooth abnormalities.
    SIMILARITY: Belongs to the integrin beta chain family. & Contains 1 Calx-beta domain. & Contains 4 fibronectin type-III domains. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1

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