• merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem
  • merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem

    产品名称:EST - CAS 88321-09-9 - Calbiochem
    产品型号:330005
    A cell-permeable, irreversible inhibitor of cysteine proteases.

    merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₃₀N₂O₅88321-09-9
    描述
    概述 A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy.
    产品目录编号 330005
    品牌系列 Calbiochem®
    同义词 Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
    参考
    参考 Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
    Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
    McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432.
    Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678.
    Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
    Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.
    产品信息
    CAS号 88321-09-9
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₇H₃₀N₂O₅
    化学配方 C₁₇H₃₀N₂O₅
    Molar Mass 342.4
    可逆 N
    结构配方图像
    生物信息
    主靶 calpain-1
    主靶IC50 10-100 µM for calpain-1
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    GHS安全信息
    RTECS RR0404300
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

    merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,PI8P01250,Millicell 插入式细胞培养皿, 12 mm, 聚碳酸酯, 8.0 µm
下一件merck millipore产品:merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem



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