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经验配方 CAS号 C₁₇H₃₀N₂O₅ 88321-09-9 描述 概述 A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. 产品目录编号 330005 品牌系列 Calbiochem®
同义词 Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d 参考 参考 Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432.
Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678.
Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.产品信息 CAS号 88321-09-9 具有ATP竞争性 N 形式 White solid Hill配方 C₁₇H₃₀N₂O₅ 化学配方 C₁₇H₃₀N₂O₅ Molar Mass 342.4 可逆 N 结构配方图像 生物信息 主靶 calpain-1 主靶IC50 10-100 µM for calpain-1 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS RR0404300 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
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