merck millipore,默克密理愽
  • merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

  • merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

    产品名称：Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem
    产品型号：217713
    The Cdk1/2 Inhibitor II, NU6102, also referenced under CAS 444722-95-6, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>

    merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₂₂N₆O₃S444722-95-6
    描述
    概述 A cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
    产品目录编号 217713
    品牌系列 Calbiochem®
    同义词 6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
    参考
    参考 Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
    Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
    Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
    产品信息
    CAS号 444722-95-6
    具有ATP竞争性 Y
    形式 White solid
    Hill配方 C₁₈H₂₂N₆O₃S
    化学配方 C₁₈H₂₂N₆O₃S
    Molar Mass 402.5
    可逆 N
    结构配方图像
    生物信息
    主靶 Cdk1/cyclin B, Cdk2/cyclin A3
    主靶IC50 9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217713,Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,330005,EST - CAS 88321-09-9 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MAB1964,Anti-Integrin β4 Antibody, clone 3E1


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