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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABT64 描述 Anti-Inscuteable Antibody Alternate Names - Protein inscuteable homolog
背景信息 Inscuteable (minsc or protein inscuteable homolog) is known to act as key regulator of spindle orientation in Drosophila. During mammalian neurogenesis, it is expressed temporally and spatially and is thought to influence the orientation of neural progenitor divisions, which are important for cell differentiation in the retina. Aside from its ability to influence the cytoskeletal structure of neural progenitor cells, it is suggested that Gi-alpha and inscuteable may play a role in regulating cellular stress associated with protein-processing pathologies. In particular, inscuteable augments the distribution of AGS3 within the aggresome whereas the AGS3 binding partner, Gi-alpha, is shown to rescue it from the aggresome. 产品信息 格式 Purified 控制 - Human liver tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Inscuteable Antibody detects level of Inscuteable & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 2 µg/mL from a representative lot detected Inscuteable in paraffin-embedded human kidney and colon tissues.
Western Blot Analysis: A previous lot of this antibody was used to detect Inscuteable in L6 cell lysates.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the human protein inscuteable homolog. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001027024
Entrez基因汇总 In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki, T., et al. (2006). Biocehm BioPhyis Res Commun. 341(4):1001-1006.). 基因符号 - INSC
纯化方法 Protein A Purified UniProt编号 - Q1MX18
UniProt汇总 FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.
SUBUNIT STURCTURE: Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN. Ref.1
SUBCELLUALR LOCATION: Cytoplasm. Note: Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells.产品使用声明 质量保证 Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Inscuteable in human liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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