merck millipore,默克密理愽
  • merck millipore,默克密理博,182516,Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

  • merck millipore,默克密理博,182516,Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

    产品名称：Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
    产品型号：182516
    The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,182516,Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,182516,Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₆BrNO₃S
    描述
    概述 A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
    产品目录编号 182516
    品牌系列 Calbiochem®
    同义词 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869, Actin Assembly Inhibitor XIV
    参考
    参考 Nolen, B.J., et al. 2009. Nature 460, 1031.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₇H₁₆BrNO₃S
    化学配方 C₁₇H₁₆BrNO₃S
    Molar Mass 394.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,182516,Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

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