merck millipore,默克密理愽
  • merck millipore,默克密理博,171256,AMPK Activator - CAS 849727-81-7 - Calbiochem

  • merck millipore,默克密理博,171256,AMPK Activator - CAS 849727-81-7 - Calbiochem

    产品名称：AMPK Activator - CAS 849727-81-7 - Calbiochem
    产品型号：171256
    The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,171256,AMPK Activator - CAS 849727-81-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,171256,AMPK Activator - CAS 849727-81-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₁FO₄849727-81-7
    描述
    概述 A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
    产品目录编号 171256
    品牌系列 Calbiochem®
    同义词 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
    参考
    参考 Kosaka, T., et al. 2005. Anal. Chem. 77, 2050.
    产品信息
    CAS号 849727-81-7
    具有ATP竞争性 N
    形式 Light yellow solid
    Hill配方 C₂₂H₂₁FO₄
    化学配方 C₂₂H₂₁FO₄
    Molar Mass 368.4
    可逆 N
    结构配方图像
    生物信息
    主靶 AMPK
    主靶IC50 EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,171256,AMPK Activator - CAS 849727-81-7 - Calbiochem

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