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merck millipore,默克密理博,529542,PSD95 Inhibitor, Tat-N-dimer - Calbiochem
产品名称：PSD95 Inhibitor, Tat-N-dimer - Calbiochem
产品型号：529542
The PSD95 Inhibitor, Tat-N-dimer controls the biological activity of PSD95. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,529542,PSD95 Inhibitor, Tat-N-dimer - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₂₆H₂₂₁N₄₃O₄₁.TFA.H₂O 描述 概述 A cell-permeable, dimeric pentapeptide (IETDV) derived from GluN2B C-terminal and linked through a polyethylene glycol (PEG)-based linker that Inhibits the ternary protein complex of PSD-95 (postsynaptic density protein-95), nNOS, and NMDA by directly binding to the tandem PDZ1 and 2 domains of PSD-95 (Ki = 4.6 nM). This inhibition results in the uncoupling between NMDA receptor activity and nitric oxide production without affecting NMDA-mediated ion channel gating function and pro-survival signaling pathways. Exhibits about 1000-fold higher potency than the monomeric Tat-NR2B9c. Exhibits improved plasma stability, with t1/2 ~ 80 hours. Shown to cross the blood-brain barrier and reduce infarct volume by about 40% and restore motor functions in mice subjected to focal ischemic brain damage. 产品目录编号 529542 品牌系列 Calbiochem®
同义词 Postsynaptic Density Protein-95 Inhibitor, Tat-N-dimer 参考 参考 Bach, A., et al. 2012. Proc Natl Acad Sci USA. 109 3317. 产品信息 形式 White solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₁₂₆H₂₂₁N₄₃O₄₁.TFA.H₂O 化学配方 C₁₂₆H₂₂₁N₄₃O₄₁.TFA.H₂O Molar Mass 2994.4 可逆 Y 结构配方图像 生物信息 主靶 PSD95 主靶Ki 4.6 nM 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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