merck millipore,默克密理博,14-916,PEK Protein, active, 10 µg

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Merck Millipore 默克密理愽

描述
产品目录编号	14-916
品牌系列	Upstate
商名	Upstate
描述	PEK Protein, active, 10 µg
概述	N-terminal, 6His-tagged, recombinant human PEK, amino acids 536-end.

产品信息
演示	50 mM Tris-HCl, pH 7.5, 0.3 M NaCl, 0.1 mM EGTA, 0.03 % Brij-35, 270 mM sucrose, 0.1% 2-mercaptoethanol, 1mM benzamidine, 200 μM PMSF

应用
应用	Active, N-terminal, 6His-tagged, recombinant human PEK, amino acids 536-end. For use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	Human PEK expressed by baculovirus in Sf21 insect cells
品种	Human
Entrez基因编号	9415
基因符号	DKFZp781H1925 PERK WRS EIF2AK3
纯化方法	Immobilised metal affinity chromatography
UniProt编号	Q9NZJ5
UniProt汇总	FUNCTION: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous. A high level expression is seen in secretory tissues. PTM: Autophosphorylated. N-glycosylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by phosphorylation of RSRSRSRSRSRSRSR. For Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -70°C

包装信息
数量	10 µg
包装	Also available in 250 µg size - call for pricing and availability and reference catalog number 14-916M when ordering the 250 µg size.

merck millipore,默克密理博,14-916,PEK Protein, active, 10 µg

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