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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB5976 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Dishevelled-2 Antibody Alternate Names - DSH Homolog 2
- DVL2
背景信息 DVL2 is a member of multigene family that also contains DVL1 and DVL3. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL2 encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein. 产品信息 格式 Purified 演示 Partially purified immunoglobulin. Liquid in PBS, pH 7.4, containing 0.01M sodium azide. 应用 应用 This Anti-Dishevelled-2 Antibody is validated for use in WB for the detection of Dishevelled-2. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000 using ECL. The antibody reacts with a protein of ~95kDa.
Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 633-645 of human disheveiled-2 protein. 宿主 Rabbit 特异性 Dishevelled-2 protein (dvl-2). By Western blot the antibody shows no cross reactivity with recombinant dishevelled-1 (dvl-1) or dishevelled-3 (dvl-3) protein. Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against disheveiled-2 protein. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004422.2
Entrez基因汇总 This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. 基因符号 - Dishevelled-2
- DVL2
UniProt编号 - O14641
UniProt汇总 FUNCTION: SwissProt: O14641 # May play a role in the signal transduction pathway mediated by multiple Wnt genes.
SIZE: 736 amino acids; 78948 Da
SUBUNIT: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts with DIXDC1 and Rac.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Phosphorylated.
SIMILARITY: SwissProt: O14641 ## Belongs to the DSH family. & Contains 1 DEP domain. & Contains 1 DIX domain. & Contains 1 PDZ (DHR) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots (not less than 10 μL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended. 包装信息 数量 50 µL
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