merck millipore,默克密理愽
  • merck millipore,默克密理博,14-855,Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg

  • merck millipore,默克密理博,14-855,Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg

    产品名称：Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg
    产品型号：14-855
    From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.

    merck millipore,默克密理博,14-855,Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg

  • 产品介绍
  • merck millipore,默克密理博,14-855,Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg

    重要规格表

    Entrez基因编号 品种 Uni Prot编号
    NM_004181.3HumanP09936
    描述
    产品目录编号 14-855
    品牌系列 Upstate
    商名
    • Upstate
    描述 Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg
    概述 Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. Mammalian neuronal cells abundantly express a deubiquitylating enzyme, ubiquitin carboxy-terminal hydrolase 1 (UCH-L1). Mutations in UCH-L1 are linked to Parkinson's disease as well as gracile axonal dystrophy (gad) in mice. In contrast to the universally expressed UCH-L3 isozyme, UCH-L1 is expressed exclusively in neurons and testis/ovary. It has been shown that UCH-L1 associates and co-localizes with monoubiquitin and elongates ubiquitin half-life and the suggestion is made that UCH-L1, with avidity and affinity for ubiquitin, ensures ubiquitin stability within neurons.
    应用
    应用 From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.
    生物信息
    来源 Recombinant human UCH-L1 expressed in E. coli
    品种 Human
    特异活性 >1000 pmol/min/μg. Determined at 25°C with 1 μM ubiquitin-AMC as substrate and UCH-L1 at 20 pM (0.54 ng/mL).
    Entrez基因编号
    • NM_004181.3
    Entrez基因汇总 UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).[supplied by OMIM]
    基因符号
    • PGP9.5
    • UCHL1
    • PARK5
    • Uch-L1
    • UCH-L1
    UniProt编号
    • P09936
    UniProt汇总 FUNCTION: SwissProt: P09936 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
    SIZE: 223 amino acids; 24824 Da
    SUBUNIT: Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.
    PTM: O-glycosylated (By similarity).
    DISEASE: SwissProt: P09936 # Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.
    SIMILARITY: SwissProt: P09936 ## Belongs to the peptidase C12 family.
    MISCELLANEOUS: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 As supplied, store at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. After initial defrost, aliquot (for extended storage it is recommended that aliquots be no smaller then 10 μL) and store at -80°C. Snap-freezing in a dry ice/ethanol bath or liquid nitrogen is recommended. As supplied, the enzyme is stable on ice for several hours.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,14-855,Ubiquitin C-terminal hydrolase L1 (UCH-L1), 50 µg

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下一件merck millipore产品：merck millipore,默克密理博,MR-025-D,EmbryoMax FHM HEPES Buffered Medium (1X), liquid, w/o Phenol Red


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