merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB411F,Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

  • merck millipore,默克密理博,FCMAB411F,Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

    产品名称：Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2
    产品型号：FCMAB411F
    Detect Bone Morphogenetic Protein 4 using this Milli-Mark Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2 validated for use in FC.

    merck millipore,默克密理博,FCMAB411F,Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

  • 产品介绍
  • merck millipore,默克密理博,FCMAB411F,Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB411F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2
    Alternate Names
    • DVR-4
    • BMP-4
    背景信息 Bone morphogenetic protein 4 (BMP4) is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.
    产品信息
    格式 FITC
    控制
    • HeLa cells
    演示 Purified mouse monoclonal IgG2b conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect Bone Morphogenetic Protein 4 using this Milli-Mark Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2 validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Recombinant mouse BMP-4 (Masuhara, 1995).
    克隆 3H2
    宿主 Mouse
    特异性 Antibody recognizes BMP-4.
    同种型 IgG2b
    品种反应性 Human
    Species Reactivity Note Shown to work on Human. Predicted to work on Mouse based on immunogen design. Unconjugated antibody (Cat No. MAB1049) was shown to work on Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_031580
    Entrez基因汇总 The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
    基因符号
    • ZYME
    • BMP4
    • BMP2B1
    • BMP2B
    • BMP-4
    • DVR4
    • BMP-2B
    纯化方法 Protein A Purified
    UniProt编号
    • P21275
    UniProt汇总 FUNCTION: SwissProt: P12644 # Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.

    SIZE: 408 amino acids; 46555 Da

    SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD (By similarity).

    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.

    TISSUE SPECIFICITY: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

    SIMILARITY: SwissProt: P12644 ## Belongs to the TGF-beta family.
    产品使用声明
    质量保证 Evaluated by flow cytometry using HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB411F,Milli-Mark™ Anti-Bone Morphogenetic Protein 4-FITC Antibody, clone 3H2

上一件merck millipore产品：merck millipore,默克密理博,MR-025-D,EmbryoMax FHM HEPES Buffered Medium (1X), liquid, w/o Phenol Red
下一件merck millipore产品：merck millipore,默克密理博,17-495,PIP3 Quantification TR-FRET Assay


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