merck millipore,默克密理愽
  • merck millipore,默克密理博,14-735M,PDGFR α (550-end, V561D) Protein, active human, 250 µg

  • merck millipore,默克密理博,14-735M,PDGFR α (550-end, V561D) Protein, active human, 250 µg

    产品名称：PDGFR α (550-end, V561D) Protein, active human, 250 µg
    产品型号：14-735M
    N-terminal 6His-tagged, recombinant, human PDGFR alpha, amino acids 550 - end, containing the V561D mutation. This V561D mutation has been found in some patients with gastrointestinal stromal tumors & More>>

    merck millipore,默克密理博,14-735M,PDGFR α (550-end, V561D) Protein, active human, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-735M,PDGFR α (550-end, V561D) Protein, active human, 250 µg

    描述
    产品目录编号 14-735M
    品牌系列 Upstate
    商名
    • Upstate
    描述 PDGFR α (550-end, V561D) Protein, active human, 250 µg
    概述 N-terminal 6His-tagged, recombinant, human PDGFR alpha, amino acids 550 - end, containing the V561D mutation. This V561D mutation has been found in some patients with gastrointestinal stromal tumors and confers constitutive activity (Hirota S et al., Gastroenterology (2003); 125:660-667 and Lasota, J. et al., Laboratory Investigation (2004): 84: 874-883).
    Alternate Names
    • platelet derived growth factor receptor, alpha polypeptide
    产品信息
    演示 10 μg of recombinant protein in 100 μL of 50 mM Tris-HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    应用 N-terminal 6His-tagged, recombinant, human PDGFR alpha, amino acids 550 - end, containing the V561D mutation. This V561D mutation has been found in some patients with gastrointestinal stromal tumors & confers constitutive activity
    主要应用
    • Kinase Assay
    生物信息
    纯度 Purity 81% by SDS-PAGE and Coomassie blue staining.
    来源 Expressed by baculovirus in Sf21 cells.
    品种 Human
    特异活性 979 U/mg, where one unit of PDGFR alpha (V561D) activity is defined as 1nmol phosphate incorporated into 250 μM GGMEDIYFEFMGGKKK per minute at 30°C with a final ATP concentration of 100 μM.
    Entrez基因编号
    • NM_006206.3
    Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
    基因符号
    • CD140A
    • PDGFRA
    • CD140a
    • PDGF-R-alpha
    • MGC74795
    • PDGFR2
    • Rhe-PDGFRA
    蛋白靶 PDGFRα
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P16234
    UniProt汇总 FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    SIZE: 1089 amino acids; 122670 Da
    SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
    SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation 250 μM GGMEDIYFEFMGGKKK. Purity was assessed by SDS-PAGE and Coomassie blue staining using 3 μg of active PDGFR alpha.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Storage and Stability: Stable for 6 months at -70 °C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-735) and in bulk (cat# 14-735-K).

    merck millipore,默克密理博,14-735M,PDGFR α (550-end, V561D) Protein, active human, 250 µg

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