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经验配方 C₉₂H₁₅₇N₂₀O₂₄P 描述 概述 A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105. Supplied as a trifluoroacetate salt. 产品目录编号 573096 品牌系列 Calbiochem®
同义词 PpYLKTK-mts, STAT3 Inhibitor IV 参考 参考 Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.产品信息 具有ATP竞争性 N 形式 White lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₉₂H₁₅₇N₂₀O₂₄P 化学配方 C₉₂H₁₅₇N₂₀O₂₄P Molar Mass 1958.4 吸湿 Hygroscopic
肽序列 H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH 可逆 N 生物信息 主靶 Blocker of Stat3 activation 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O 肽序列 H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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