merck millipore,默克密理愽
  • merck millipore,默克密理博,14-616,MSK2 Protein, active, 10 µg

  • merck millipore,默克密理博,14-616,MSK2 Protein, active, 10 µg

    产品名称：MSK2 Protein, active, 10 µg
    产品型号：14-616
    Active, N-terminal His6-tagged, recombinant, human MSK2, amino acids 2-end, for use in Kinase Assays.

    merck millipore,默克密理博,14-616,MSK2 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-616,MSK2 Protein, active, 10 µg

    描述
    产品目录编号 14-616
    品牌系列 Upstate
    商名
    • Upstate
    描述 MSK2 Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant, human MSK2, amino acids 2-end
    应用
    应用 Active, N-terminal His6-tagged, recombinant, human MSK2, amino acids 2-end, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_003942.2
    • NM_001006944.1
    Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
    基因符号
    • RSKB
    • RPS6KA4
    • MSK2
    • RSK-B
    蛋白靶 MSK2
    纯化方法 Purified using Ni2+/NTA-agarose. Activated using MAP Kinase 2/Erk2, active (Catalog # 14-173) and repurified using Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • O75676
    UniProt汇总 FUNCTION: SwissProt: O75676 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser- 10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto- oncogenes FOS and JUN (By similarity). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
    COFACTOR: Magnesium.
    SIZE: 772 amino acids; 85606 Da
    SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
    SUBCELLULAR LOCATION: Nucleus.
    SIMILARITY: SwissProt: O75676 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
    MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains (By similarity).
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of 30mM Crosstide (Catalog # 12-331)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-616,MSK2 Protein, active, 10 µg

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下一件merck millipore产品：merck millipore,默克密理博,05-967,Anti-Ago4 Antibody, clone 5F9.2


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