merck millipore,默克密理愽
  • merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

  • merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

    产品名称：TrkB Recombinant Human Protein, Active, 250 µg
    产品型号：14-507M
    Active, N-terminal His6 tagged, recombinant, human TrkB, amino acids 455-end, for use in Kinase Assays.

    merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

    描述
    产品目录编号 14-507M
    品牌系列 Upstate
    商名
    • Upstate
    描述 TrkB Recombinant Human Protein, Active, 250 µg
    概述 N-terminal His6 tagged, recombinant, human TrkB, amino acids 455-end
    应用
    应用 Active, N-terminal His6 tagged, recombinant, human TrkB, amino acids 455-end, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006180.3
    • NM_001007097.1
    • NM_001018064.1
    • NM_001018065.1
    • NM_001018066.1
    Entrez基因汇总 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
    基因符号
    • Trk-B
    • NTRK2
    • GP145-TrkB
    • TRKB
    蛋白靶 TrkB
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • Q16620
    UniProt汇总 FUNCTION: SwissProt: Q16620 # Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.
    SIZE: 822 amino acids; 91999 Da
    SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
    PTM: Ligand-mediated auto-phosphorylation.
    SIMILARITY: SwissProt: Q16620 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-507) and in bulk (cat# 14-507-K).

    merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

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